I'm still waiting on the final payment of a 2022 BTC denominated large contract that finished late 2024. I did receive 3 milestone payments. When I asked for my money the answer was "let us get a loan" and then I was ignored - since over 5 months now. I'm probably not going to get it... hate to write off large amounts of money.

Other (smaller) contracts denominated in BTC went much better. So it's possible, but I'd recommend against large projects that take long, unless you have good relations. Even then, make sure you get paid more frequently than you would in fiat.