Agree it takes guys awhile to get into game shape and these injuries are part of that but the Bills probably don't need the reps as much. 49ers are going to have at least 4 new starters on D and up to 7 depending on how rookies play and who is healthy going into week 1. On offense its not as bad they will likely have just 2 new starters. 

grayruby

Stacker_Sports

49ers First Preseason Game- My Takeaways

>Biggest concern- More guys injured. The 49ers have managed to avoid major injuries so far this camp and preseason with just one player getting an injury that will likely carry over into the season but they have been decimated by minor nagging injuries- calfs, hamstrings, ankles, knees. I know they are really trying to protect guys this year because they know they don't have the depth to sustain a lot of major injuries but this is a team with a ton of new players that needs to get solid reps in practice and preseason.

Bills are dealing with this as well. I think all teams are in this boat. Training camp is brutal 