Only do it if you are confident you income won't be impacted by an economic downturn and that you can comfortably afford the monthly loan payments from your fiat income. You don't want to have to sell and then watch it go up 10x because you used too much leverage or your income wasn't as secure as possible.

I did a small bitcoin backed loan on Ledn but I closed it out early because I was concerned about the changes they were making to the product and services and purchase of a crypto investment fund. Worked out well though, I put up 10M sats to back a loan for another 10M sats at around 19k and I think we were at 25k when I closed it out. I paid 8% interest for 6 months or so.