What do you think WILL change with the nature of our work?
It will be increasingly indirect and abstract as all well-defined rote work is automated. We will work more because the work we do is less difficult with the work itself terminating on us doing the work of entertaining each other. Remote will stay and VR will prove a sufficient substitute for anything that benefits from air sharing. I think we'll see The Firm (in Coase's sense) degrade some as transaction costs come close to elimination.
Perhaps more importantly, what do you think WILL NOT change?
That people will find purpose in doing things for other conscious beings. That is the only absolute imo.