I wonder the same. TBH, by reading this article, I suspect it's of any use. I think it's the political influence of Johnson and Johnson that has helped get a grant for this spray. I like ayurvedic medicines for depression. We've a plant of night Jasmine in our yard and it has helped all of us to remain healthier and happier.

Spravato is for the therapy of treatment resistant depression. When all other options fail (other antidepressants, psychotherapy) Spravato might help. It is also effective against acute suicidial thoughts. The active pharmaceutical ingredient is ketamine which has the advantage that the effects set in almost immediatly. Moreover, they last for several days or in some cases even weeks. The main disadvantage is its addictive potential.