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0 sats \ 9 replies \ @Lux 28 Feb \ parent \ on: Fun Fact Friday - Best Fun Fact Gets 5,000 CCs meta
The protein levels of p53 and p21 increased upon the treatment with albendazole and fenbendazole, indicating activation of the p53–p21 pathway, while the levels of Mdm2 and MdmX decreased in melanoma and breast cancer cells overexpressing these proteins. We also observed a reduction of cell viability and changes of cellular morphology corresponding to mitotic catastrophe, i.e., G2/M cell cycle arrest of large multinucleated cells with disrupted microtubules.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6600429/
TIL
Mitotic catastrophe has been defined as either a cellular mechanism to prevent potentially cancerous cells from proliferating or as a mode of cellular death that occurs following improper cell cycle progression or entrance
Ok, so I was wrong with the mutations. Fenbendazole is supposed to block the interaction between p53 and its regulator Mdm2. Good luck with that. Many inhibitors from nutlins to don’t know what have failed in the clinics so far. Mostly because of serious side effects. Can fenbendazole spare the healthy cells?
I am sorry but what is this paper supposed to show? That there is some effect in a cell culture on a petri dish?
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I am indeed but no, thank you, I won’t watch the video nor read the comments. But I skimmed through the paper, it could be good basic research though, however, still miles from being used in cancer treatment. Are there any in-vivo experiments?
Is this the DRUG that governments are hiding from us? 😬
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Are there any in-vivo experiments?
https://pubmed.ncbi.nlm.nih.gov/15565325/
i guess anecdotal is not scientific ;)
is this the DRUG that governments are hiding from us?
Don't know, don't care.
It works.
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