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Hello!... If you use the default builtin setup, I'd say 99% of your habitual browsing is not going to be affected and you'll enjoy an add and tracking free experience most of the time.
In the extreme way I use it, yes, that's problematic. I'd say at least once every month some new site, software or service I visit or use doesn't load or doesn't work correctly because there's something being blocked and I have so spend some time looking for what's being blocked to add it to my allowlist. But that's my extreme case. I don't think there's many people as crazy as me, haha.