Metrics can vary based on individual investor lenses but in general user engagement, monetisation and evidence of opportunity to scale may be a few metrics that highlight how sustainable is the enterprise and how much value it delivers and as well captures

It is a bit more difficult with bitcoin as there is a monetary system and internal economics that impact how value is produced, accumulated and distributed. And there are also metrics that are simply a derivative of the scale of adoption. And there may be new metrics fundamental to how bitcoin economy works (especially metrics related to the lightning network, but also onchain and mining) But in theory a startup should be able to produce metrics that resonate with both bitcoin and non-bitcoin VCs

Metrics are a means to making business decisions so they should be relevant for the dimension about which decision is being made