In terms of debt to buy bitcoin... I would only ever consider it in the event of being prepared for a scenario where violence is used against you to hand over physical assets e.g. if you have a house you own with a family in it, you're probably not in a good position to tell creditors to fuck off.
Now, that doesn't mean it is likely you even have to get there, especially if you don't have a trivial to find physical location (though most people live wherever their drivers license says). Debt is not as scary as people make it out... debtors will capitulate and be like "so you owe use $10... Would you please give us $3 and call it even?"
I was trying to build a debt tool that is cryptographically unrehypothecatable... I think it will get built by someone at some point, but would not be easy.