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Yes, especially the Democrats' level of trust for what the FBI and the CIA says has entirely 180'd from the end of the Bush years to the start of the Trump years (and it's 180ing again)
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Big Pharma was a bad guy for the left, too. I'm sure, as with other corporate interests, the politicians were always on the take, but lefties didn't used to knowingly parrot whatever pharma execs said.
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During the Bush years, at least, the Democrats preached a lot of skepticism of the intelligence agencies and corporate science.
That's pretty different from, say, the Covid era.