Nscale Ltd., the AI cloud computing firm, is in talks to sell computing power to Anthropic PBC in a deal that could be worth about $45 billion, according to people familiar with the negotiations.

The Nvidia Corp.-backed data center developer is seeking a second major deal with the firm behind Claude for a second facility at its Monarch data center campus in West Virginia, the people said. Anthropic has agreements in place with Nscale for infrastructure that’s worth as much as about $44.6 billion, according to a regulatory filing for Nscale’s planned initial public offering.