Wireless keyboard and mouse.
I was very skeptical of everything wireless. I still am, especially when it comes to LAN vs WLAN, but I must admit that it's really nice to have less cables on my desk.
Sometimes, there is indeed a small hiccup (which I assume is because it's wireless) but it's still better than to have to deal with the cables.
Next thing will be wireless headphones. I would love to upgrade my existing headphones (Beyerdynamic MMX300) but seems like there is no such thing even though the cable is removeable ...
What mouse and keyboard did you go with?