Here's advice I never received, but I'll offer it to others in case it's useful.

Some people go to Rio and live roughly the same life they'd live if they went to London or Istanbul. I'd say: do things that can only be done in the place where you're going. I think this is true in your normal life, too, and not just in space, but in time: maximize the opportunities of being the person you are right now, in the place and time you are.

I struggle to live into this but it's something I believe with all my heart.