In my experience, the bufo medicine is best sat with in the desert on the earth. The energies that come through are intense and being grounded is helpful. Science agrees with this. We are energetic beings. When I am in the medicine I am always called to earth. I have never sat in a clinical setting and I have never used a synthetic varient. To me, everything is energy. So where something come from matters. I like the thing I can trace to the earth and connect with on an energetic level. I don't know how to connect with a thing that is synthesized. To me, there is more to a thing than what our human minds and science can comprehend. So I prefer the natural setting, non clinical, more shamanic approach. But that doesn't mean that 5meo-dmt in a more clinical setting can't be great. I just like the other approach. Everyone is called to different types of experiences and at the end of the day, the best setting is the one where the participant feels safe to have the experience and connect. And that may look very different for different people. Just my opinion. Thanks for the great question.