I have found that there are a few substances that have had no effect on me, while I am incredibly sensitive to others. There have been times that I knew something wouldn't affect me and then it didn't. I was given general anesthesia and it didn't take me out all the way. Crazy story. My take away is everything is a placebo. -Joe Disoenza. Our thoughts create our reality. And every individual has their version and their own beliefs around what they consume. So it is totally possible to just not have a trip when most others would.