I think SAAS businesses make the most sense to move to Bitcoin, the one pain point for SAAS is despite being globally available dealing with payments is a ball ache, slow and you take on a lot of risk providing your service with this delayed settlement.
So they're forced to make these shitty packages with step functions, to make up for it, forcing customers to buy resources they won't use instead of selling them per use or itemised use
These packages limit their reach as it's a larger commitment for the user and also reduce conversion rates as customers don't get to discover the product and its benefits because the free version or low-end version is proper shit
By moving to LN/Bitcoin you open up pay-per-use models that give more users access, and a better scope for what users want, their interests, what they are willing to pay for and double down on that info to improve your product
As you also get more out of your user base, you can further lower prices or create more competitive packages that will force your competitors to adopt Bitcoin or die ignoring it
Coming from Agency tools like Hubspot, Sharpspring, Brevo, Ahrefs, SEMrush, Onesignal, Buzzsumo, Asana, send in blue would make bank.

Ad networks

Other than that ad networks make the most sense, if you're not using Googles GDN and you use smaller networks or niche networks, paying and getting paid is proper shit, you have to wait months for a payout as a publisher and funding your account as an advertiser takes its own sweet time
While you can do direct deals today with businesses and settle in Bitcoin, there's a lot of trust involved, and if you could have something like a DLC that triggers based on impressions served that could work better