Nah bro, I have been cancelled by a number of people... even childhood friends... for political wrongthink. There was no argument or conflict - I posted a photo of me at an event for a political candidate they disagreed with and they unfollowed, etc.

I know someone who lost a friend of 40+ years for being unvaccinated: the woke friend was so terrified of COVID she refused to meet in person for over 2 years unless the other friend wore a mask in her presence. The unvaccinated friend politely refused to mask up. Their friendship deteriorated rapidly and is basically non-existent today.