Qubes OS is highly recommended for securely handling USB drives due to its robust isolation capabilities. It segregates applications into separate virtual machines, ensuring that malware from a USB cannot compromise your entire system. This isolation helps maintain security without sacrificing usability, making it a top choice for those concerned with digital security.

Alternatively, using a bootable OS like Tails or a live Linux distribution provides a temporary, secure environment for safely checking and transferring files from a USB drive. These systems don't affect your main operating system, as they run independently from a USB or CD and automatically erase traces of their use upon shutdown.