I guess if you really want to you can pay Chainalysis to screen incoming channel opening requests.
Does your whole Lightning Node suddenly become tainted?
As soon as a random drug buyer opens a widest possible channel of 4M sat (~$1000) to you, you will be sanctioned by US Treasury and no American will be able to have business with you. Anthony Blinken himself will tweet that US will aggressively pursue criminals like you. Or maybe none of that will happen, who knows.