Thank you for your response and even as the one who wrote this post, your distinction between significant and best has got me thinking about choices I have made in my 20s that were significant but maybe not the best or most positive. 

BTCFC

Bell_curve

My most significant choise was - choosing to travel and focus on career, ahead of relationships and starting a family.

Other people are taking this question as "what are the best choices you made in your 20's".

But I'm taking it as written, the most significant choices. And delaying relationships/family was a significant choice.

It's one that I would have made differently could I do it over again.

alter_native

What are some of the most significant choices you made during your 20s?

My most significant choise was - choosing to travel and focus on career, ahead of relationships and starting a family.

Other people are taking this question as "what are the best choices you made in your 20's". 

But I'm taking it as written, the most significant choices. And delaying relationships/family was a significant choice. 

It's one that I would have made differently could I do it over again.
