There are academic papers with reams of data with observable effects and conjecture about what this means for genetic experimentation, but the problem (as I understand) is that we have only started genetic sequencing in the last sixty years. In a rational, cautious world there would be longer memorandums on experiments in biochemistry/bio-tech, such as CRISP-R gene editing, cloning and mRNA moving from in vitro to in vivo. So, the time frames discussed are relatively short to evolutionary timescales, and meaningful data would come from meaningful timescales. This has not yet elapsed.

In terms of biology, we still do not understand many of the implications of viral disease, the evolution of pathogens, and how this connects holistically to ecological science. I don't know much more than this being the general state of science. I couldn't point you to any conclusive data.