24 hours after the loss of Carlos Alcaraz, 24-time Grand Slam champion Novak Djokovic is out from in USopen 3rd round to Alexei Popyrin 6-4, 6-4, 2-6, 6-4.

This is the first major since the 2004 French Open without Djokovic, Nadal or Federer in the Round of 16.