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Highlights Multicenter design, covering a population of 20 million inhabitants over 12 years. Low incidence affecting mainly middle-aged males during heterosexual intercourse. Cardiac origin, mainly due to ischemic heart disease that remained silent in life. Frequent association with use of cocaine and medications for erectile dysfunction. Relative high of frequency of obesity and performing unusual sexual practices. https://www.sciencedirect.com/science/article/abs/pii/S0379073823003584