One thing I've noticed with chronic users is dependency on it just as with other opioids, however it's more natural and less ill side effects. Things like nausea, headaches, and stomach issues can happen to certain people especially with higher dosages. I've experienced nausea myself and white veins is too stimulating for me. So I think it all depends on strain, dosages, and the individual just like anything you know. So if I had to prescribe this to a patient or client I would keep these things in mind, just like the other herbs/formulas I would use.

NEVER A ONE SIZE FITS ALL FOR ANYTHING.