Federal prosecutors never charged Ulbricht with attempted murder, but the federal judge who sentenced him to two life sentences plus 40 years with no possibility of parole nonetheless referenced these episodes in her decision.

She also said that Ulbricht should serve as a public example for acting as though he "was better than the laws of this country."

In 2015, Forrest presided over a jury trial in United States v. Ulbricht, where Ross William Ulbricht was accused of running the Silk Road online drug marketplace.[19] During the course of the trial, Forrest was doxed on 8chan, where her full mailing address, phone number, and Social Security number were posted on the baphomet subboard.[20] In regards to the defense team's argument that Silk Road enhanced safety by moving illegal drug activity away from real life drug dealing scenarios, Forrest stated "No drug dealer from the Bronx has ever made this argument to the court. It's a privileged argument and it's an argument made by one of the privileged."[21] Forrest sentenced Ulbricht to two life terms, plus an additional 40 years, without the possibility of parole.[22] The Department of Justice then subpoenaed Reason Magazine regarding reactions in the comments section of its article on the sentencing.

Following her resignation from the federal bench, Forrest returned to practice in the litigation department at Cravath, Swaine & Moore.[36] In 2019, she was named a “Notable Woman in Law” by Crain’s New York Business and profiled as one of Benchmark Litigation’s “Top 250 Women in Litigation”.[37] Forrest is also an adjunct professor at New York University School of Law, where she co-teaches a course on Quantitative Methods and the Law.

Forrest represented the Boston Red Sox in a proposed class action alleging that the Major League Baseball team had undermined fantasy sports contests by covering up sign stealing schemes in a case that was dismissed with prejudice in April 2020.

"What Silk Road really was, was a social market expander of a socially harmful drug that we have deemed in our democratic process to be unacceptable and it was an enabler of those trying so very hard to get away from it. What you did in connection with Silk Road was terribly destructive to our social fabric"