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While its not the worst thing in history, 2 inventions Thomas Midgley Jr. had a very long tail of influence in the 20th Century, resulting in significant environmental and human damage:
  • Lead in Gasoline (poisoning the brain of humans, and he knew and downplayed the risks; A measurable loss in global intelligence)
  • CFCs (stripping the planet of its ozone layer which offers protection against UV radiation; A measurable gain in cancer, etc)