Of course there are some drugs more destructive than alcohol (i mean mainly opioids), but still huuge majority of substances known as psychoactive, especially those of natural origin (and still illegal), are less harmful, and objectively better for health&surroundings.

I'd say alcohol is easily in top3 in terms of being harmful and toxic substances, while you can find dozens of lighter ones. It's really sad that alcohol is the legal, accepted and popular one. Also it is not even that fun, that shit is actually degrading for your brain in the long run