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Every time I feel like I should save something encrypted—especially because my NixOS installation is not using FDE, but that's a story for another day—, I realize I have no idea how to do this except that it should be possible with openssl which is quite embarrassing as the founder of ~crypto and ~security.
So I am writing this post to never need to look at the massive manual for openssl just to encrypt a file again.
Encryption
Encrypt file with AES-256-CTR, use PBKDF2 as the password hashing algorithm and use base64 encoding for the output:
$ openssl enc -aes-256-ctr -pbkdf2 -a -in <file> 
will prompt for password
Decryption
Same as above with but -d:
$ openssl enc -d -aes-256-ctr -pbkdf2 -a -in <file> 

Btw, I used AES-256-CTR here because I know it should be safe and I don't want to research all the other ciphers I could use. Maybe ChaCha20 would be safer??
Which cipher would you use to store, say, an API key? Would you even use openssl for that since it's quite low-level and you can probably easily shoot yourself in the foot with it?