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Bacteria on your skin cause your itches. Specifically, bacteria known as Staphylococcus aureus can release a chemical that activates a protein in our nerves. This sends a signal from our skin to our brains, which our brain perceives as an itch.Bacteria on your skin cause your itches. Specifically, bacteria known as Staphylococcus aureus can release a chemical that activates a protein in our nerves. This sends a signal from our skin to our brains, which our brain perceives as an itch.