I use Tails for many things, including web browsing and various secure document management. And also some bitcoin stuff.

You can use it as a "poor man's hardware wallet". It comes with Electrum, nicely integrated with Tor. The idea is that Tails is a very security-hardened environment, so you can use it as a hot wallet where you actually enter your seed into Electrum (or have Electrum generate it). Then use it to transact like we did in the old days! You can pair it with a watch-only wallet on your regular device, where you create transactions and then transfer the PSBT into Tails to sign it.

However, don't settle for a poor man's solution like this unless you're poor. If you have a decent amount of money to secure, get a proper hardware wallet. You can combine that with Tails too, using it for wallet management and transaction production (it works nicely with many hardware wallets).

Tails, in general, is a great little tool. It's good to be familiar with it.

Definitely not a Ledger. The security issues with Ledger are not pretty.

If you did buy a hardware wallet, make sure it's Bitcoin only - that limits the list quite a bit. And also I suggest that you use Sparrow Wallet to coordinate transactions, instead of any wallet software associated with the hardware wallet.

If you want to pursue the USB stick option - here's some detailed instructions on how to create a wallet with a USB stick/TailsOS written up by @Natalia a while back How to MAKE your own Cold Wallet 🕶️.