It really depends on what you're trying to build.

Frontends and web-applications and basic business logic type stuff, you can likely expect decent results.

More complicated applications, with many moving parts, or specialised domain, or performance requirements, you're likely to hit the edges of the current state of the tooling. And depending on how far you continue in building such a project without much critical review, you WILL end up in a hot mess.

From what you say, "a little Python thing to do this simple task with all my excel sheets", you can probably expect good results.

The worst thing you can do is not try IMO!!