Adults with chronic insomnia who used melatonin for a year or longer faced a 90 percent higher risk of developing heart failure within five years compared to non-users.
The preliminary analysis, presented Monday at the American Heart Association’s Scientific Sessions 2025, tracked more than 130,000 adults diagnosed with insomnia. Among those who took melatonin for more than a year, 4.6 percent developed heart failure, compared with 2.7 percent of nonusers.
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basically, there's no free lunch. You gotta be so careful when taking any quantity of refined substances.
Co-relation does not equal causation. This is an observational study, it does not show that melatonin causes heart failure.
FTA:
Note also that the melatonin users in the study were prescribed melatonin, which probably means it was a much higher dose than what over-the-counter users take, often 1-3mg. But those details weren't mentioned in this article.
And this:
For what it's worth, I think OTC dosage (1mg 3mg sometimes 5mg) is way too strong.
Break a tablet in half or quarter. 0.1mg to 0.5mg still works, often just as well as 1-3mg. Pretty sure there were studies to back this up.
What about with kids?
Wow glad I never went down this path of taking melatonin