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After 60 Years, Diabetes Drug Found to Unexpectedly Affect The Brainwww.sciencealert.com/after-60-years-diabetes-drug-found-to-unexpectedly-affect-the-brain
338 sats \ 2 comments \ @ch0k1 23 Nov science
Metformin has been prescribed to people with type 2 diabetes to manage blood sugar for more than 60 years, but scientists haven't been exactly sure how it works. A recent study suggests it works directly in the brain, which could lead to new types of treatment.
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121 sats \ 0 replies \ @DrBrader99 23 Nov
The exact moa is not known, but it decreases gluconeogenesis and increases insulin sensitivity, unlike sulfonylureas, which would cause hypoglycemia
In their 2025 study, tests on mice showed metformin traveling to the VMH(a brain part), where it helps tackle type 2 diabetes by essentially turning off Rap1.
Thats also one of the proposed moa of metformin recently
When the researchers bred mice without Rap1, metformin then had no impact on a diabetes-like condition – even though other drugs did. It's strong evidence that metformin works in the brain, through a different mechanism than other drugs.
this drug is very safe first line in newly diagnosed type 2 It doent have major side effects and its a very inexpensive drug
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21 sats \ 0 replies \ @SHA256man 24 Nov
drugs that affect the brain with unclear consequences are demon drugs; currently, Ozempic is in a similar category of demon drugs; people can intellectualize the usefulness of these drugs until they are blue in the face; "peer-reviewed" papers are a trap for the intellectuals; all of these substances are designed to maintain brain rot and a comfortable environment for parasitic infestation; contemplate on my work in bio;
#1279063
people have a diseased mind; instead of following the most obviously healthful way of life, they fall for life hacks, which the academons gladly provide on a rolling basis;
my parasitic theory of disease postulates that the parasites have hijacked the mind;
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