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If I am just using this for myself, is it ok if the Lightning node is offline for hours or days at a time?
If you are just running it for yourself (private node) and not using it for routing payments (routing node), then it's okay, yes. It only needs to be online when you want to receive payments.
In order to continue to use Blue Wallet, do I have to set up my own Lndhub instance, or can I drop something else in place, or can Blue Wallet connect to LND directly?
I think it only works with LndHUB but I am not sure.
Also, what should I be aware of in terms of backing up that way if something happens to my laptop I can restore my Lightning Node on a new machine?
There should be docs. I use CLN and there was mentioned which files need to be kept private and secure. It also has a config option to continuously backup the sqlite database at a different location.