That shouldn't be the takeaway. The takeaway should be popularizing multisig models that use things like 2fa (mobile key and desktop key) to authorize transactions and slowly fading out single sig hot wallets.
Can you 2fa any wallet with a yubikey?
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I was thinking of using a desktop wallet to generate a signed psbt that would get scanned via qr code to one's phone before getting signed and broadcast there.
I haven't seen any articles about trying to use yubikeys to make ECDSA secp256k1 signatures from this year but it seems possible with some manual intervention (see the comment in the 1st link). Here are some of the newer articles I found from google: