Maybe we won't be able to recreate it 1:1, but I think advanced robotics, combined with "human-like" abilities in regards to complex thinking could be dangerous enough- imagine a computer that has no cap of learning, and is free to do with that information whatever it wants. The newfound knowledge would dwarf ours pretty quickly.

Fabs

science

What possible future (technological) breakthrough might be a grave mistake?

I am skeptical that the human mind could be replicated, we have no working theory of how conciousness works. I personally presume that its not anything that can be conventionally explained; maybe your body and brain is remote controlled through the microtubules in your brain, and you are really some 5th dimensional being. If that sounds crazy, at least theres an open lead on it, compared to reducing the human being to computation, for which we have no serious path forward.