That's the one - 2038 which we're fine until (I believe) year 2106. If there will be a hardfork to fix that, we might bundle more things into it. Cutting satoshi into another 100 million bits could be another one. That would also make new halvings possible - half sat per block, followed by a quarter of sat for years later and so on (21 million would still be intact in this case). Quantum resistance, larger block space and whatever necessary might find its way into that single hardfork too.

I don't pretend to see the future, just thinking of the possibilities. Some shitcoiners don't realise that never is a really long period of time.