Researchers used mitochondrial gene editing to model genetic disorders in mice, revealing profound impacts on brain function, metabolism, and thermoregulation. They employed a specialized DNA editing tool to induce mutations in the ND5 mitochondrial gene, disrupting energy production and causing learning deficits, hippocampal atrophy, and obesity.

The findings provide a powerful framework for exploring mitochondrial gene function and developing targeted therapies for mitochondrial diseases. This research may pave the way for treatments addressing neurodegenerative conditions and metabolic disorders linked to mitochondrial dysfunction.