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Favorite 2.0: The Podcasting 2.0 Podcast – oh, how meta is that? Hehe, it‘s because they talk a lot about the development, how to approach Podcasting 2.0 and they explore this new space. That‘s what I like about it. And listening to Adam Curry is entertaining.
Favorite in general: Stephan Livera does a very good job on economic and technical topics, I really like what he does!
Lesser known: Bitcoin OP_UXUI, very good in-depth discussions about user experience and related things in Bitcoin.
The german scene has some very good shows as well, they obviously are for a german-speaking audience, but tbh I have weeks in which my backlog is so full, that I can listen to very good content from my home country only.