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37 sats \ 13 replies \ @Lux 28 Feb \ parent \ on: Fun Fact Friday - Best Fun Fact Gets 5,000 CCs meta
wash your ears
References
Lacey, E. (1974). The benzimidazole anthelmintics—a review
Patel, K., & Bhuyan, R. (2021). Antitumor activity of albendazole against the human colorectal cancer cell line
Choi, S. H., Martinez, M. N., & Weatherly, L. M. (2018). Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways
Johnston, M. D., & Read, A. F. (2018). Repurposing anthelmintic drugs as cancer treatments: perspectives from evolutionary biology
Morris, G. M., & Keppler, D. (2019). The role of anthelmintic drugs in the treatment of cancer
Mukhopadhyay, T., Sasaki, J., Ramesh, R., & Roth, J. A. (2018). Antitumor effects of fenbendazole: A possible role of microtubule disruption
Lacey, E., & Morrell, A. (2013). Benzimidazoles in cancer therapy: repurposing anthelmintics for oncology
Pedersen, P. L. (2013). Hexokinase II: Cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
Have you read these references? If it used in the clinics?
p53 can carry various mutations in different places. I know about some drugs in the clinical trials targeting y220c mutation for the protein reactivation, still miles from approval, often with serious side effects. All the other mutations (or most of them) are considered undruggable.
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most clinics do not know what the fuck they are doing. the health providers in most clinics have been heavily indoctrinated. why do all domesticated mammals undergo a deworming procedure yearly, except humans? oh right, people are supposed to fast... but they DON'T, ever since break-fast became the "most important sugar-rich meal of the day!"
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Feel free to deworm yourself if you think this is a good idea… if e.g. you eat a lot of raw uncooked food.
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The protein levels of p53 and p21 increased upon the treatment with albendazole and fenbendazole, indicating activation of the p53–p21 pathway, while the levels of Mdm2 and MdmX decreased in melanoma and breast cancer cells overexpressing these proteins. We also observed a reduction of cell viability and changes of cellular morphology corresponding to mitotic catastrophe, i.e., G2/M cell cycle arrest of large multinucleated cells with disrupted microtubules.
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TIL
Mitotic catastrophe has been defined as either a cellular mechanism to prevent potentially cancerous cells from proliferating or as a mode of cellular death that occurs following improper cell cycle progression or entrance
Ok, so I was wrong with the mutations. Fenbendazole is supposed to block the interaction between p53 and its regulator Mdm2. Good luck with that. Many inhibitors from nutlins to don’t know what have failed in the clinics so far. Mostly because of serious side effects. Can fenbendazole spare the healthy cells?
I am sorry but what is this paper supposed to show? That there is some effect in a cell culture on a petri dish?
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I am indeed but no, thank you, I won’t watch the video nor read the comments. But I skimmed through the paper, it could be good basic research though, however, still miles from being used in cancer treatment. Are there any in-vivo experiments?
Is this the DRUG that governments are hiding from us? 😬
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Are there any in-vivo experiments?
https://pubmed.ncbi.nlm.nih.gov/15565325/
i guess anecdotal is not scientific ;)
is this the DRUG that governments are hiding from us?
Don't know, don't care.
It works.