I really enjoy using obsidian.md, espcially since it let's do many things fast. Here are some of the top shortcuts I like to use, some standard, but a bunch of them custom.
I'm using 2 plugins to enable those: Shortcuts Extender, and Code Editor Shortcuts.

Standard and really useful shortcutsStandard and really useful shortcuts

• Use tab to indent the item in the list more, use shift+tab to un-indent.
• Use cmd+I to make the text italics
• Use cmd+B to make the text bold
• Use cmd+K to add a link or make existing text into a link
• Use cmd+, to open Settings (works in any app on MacOS)
• Use cmd+shift+8 to create a bullet list (if you use it on existing text it makes it bulleted)

Obsidian Custom Keyboard ShortcutsObsidian Custom Keyboard Shortcuts

• cmd+P - Open Command Pallete to issue any command (matched with VSCode)
• cmd+shift+P - Open Quick Picker to pick files (matched with VSCode)
• cmd+return - toggle a checkbox (this used to be default, but now needs custom)
• cmd+R - Navigate Back (to previous document)
• cmd+shift+B - Toggle left sidebar
• cmd+shift+H - Toggle right sidebar
• cmd+shift+M - Move current file to another folder
• cmd+shift+R - Reveal the current file in the browser on the left
• cmd+shift+9 - Create a checkbox list
• cmd+shift+T - Insert template (either Templater or default)
• cmd+shift+N - Split view to the right
• cmd+D - Select word occurence with multiline editing cursor (using Code Editor Shortcuts)
• cmd+shift+UP - Move line up (using Code Editor Shortcuts)
• cmd+shift+DOWN - Move line down (using Code Editor Shortcuts)
• cmd+shift+D - Duplicate the current line (using Code Editor Shortcuts)
• option+cmd+1 - Heading 1 (using Shortcuts Extender)
• option+cmd+2 - Heading 2 (using Shortcuts Extender)
• option+cmd+3 - Heading 3 (using Shortcuts Extender)
• cmd+shift+F - Omnisearch (needs Omnisearch plugin)
• cmd+W - Close active pane

CombosCombos

• cmd+shift+B+H - hide both sidebars (using above shortcuts)
• hold cmd, hit D, hit K, hit V - highlight just written word, linkify it and paste URL from clipboard