For 170 Years, No One's Known How General Anaesthesia Works (2020)www.sciencealert.com/for-over-150-years-how-general-anaesthesia-works-has-eluded-scientists-we-re-finally-getting-close
490 sats \ 16 comments \ @south_korea_ln 16 Jul science
But although we know that it knocks us out and messes with our consciousness, the actual mechanism behind general anaesthesia was unknown when we first found it, and we still don't have a full explanation.
"That's been a great mystery for about 170 years," Alfred Hospital and Monash University anaesthesia researcher Paul Myles told ScienceAlert. "The straightforward answer is 'no one really knows'."
Anaesthetists are basically just following recipes without really knowing why they work... and sometimes... don't work.
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118 sats \ 0 replies \ @Akg10s33 16 Jul
My best friend is a graduated anesthesiologist, he works in a public hospital... and on occasions we have talked about his daily life and the experiences he lives and what happens to him with patients. It is not easy at all because practicing that profession is 20% knowledge and 80%. % the responsibility that it implies... and that responsibility depends on those few ml that the professional can place more or less at the time of the patient's sleep and perform some operation... those who wake up often do so with side effects such as intense pain headache... or blindness or no taste in your mouth... and the truth is that some do not wake up... cases where the dose was not correct and the anesthesia led to the death of the patient... and the first thing they do is directly the legal actions against the anesthesiologist... the truth is a quite complex issue and as can be seen in the article it remains a mystery as to what its true effect really is...
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13 sats \ 2 replies \ @fm 16 Jul
and we still don't have a full explanation.
This is my favorite part :)
The combo used is interesting..
Propofol, etomidate, and ketamine are the intravenous (IV) sedative-hypnotic agents commonly used to induce general anesthesia , while adjuvant agents (eg, opioids, lidocaine, midazolam, and volatile anesthetics) are often used to supplement the effects of the primary sedative-hypnotic induction agent
And this is why you need a whole specialization to administer these. I heard there are a huge number of drug users among anesthesiologists.
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11 sats \ 1 reply \ @Bell_curve 16 Jul
This is true. I have a classmate who was an anesthesiologist and a drug addict.
I have heard other doctors such as surgeons say the same. Great anesthesiologist was fired for drug use
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13 sats \ 0 replies \ @fm 16 Jul
its very tempting.. they have access to all those wonder drugs..
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13 sats \ 1 reply \ @SpaceHodler 16 Jul
An article suggesting a connection between the conscious experience and quantum phenomena.
https://www.caltech.edu/campus-life-events/calendar/anesthetic-action-links-consciousness-to-quantum-vibrations-in-brain-microtubules
Consciousness operates in a multi-scale hierarchical cascade, originating in terahertz quantum dipole oscillations in tubulin pi resonance clouds in microtubules, resonating upward in structural size, slowing in frequency through gigahertz, megahertz, kilohertz and hertz frequency ranges (EEG arising from 'interference beats'). Anesthetics dampen the quantum oscillations, slowing cascade resonance and preventing consciousness. The brain may be more like a quantum orchestra than a classical computer.
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13 sats \ 0 replies \ @itsrealfake 16 Jul
See also, Roger Penrose
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13 sats \ 0 replies \ @Msd0457890 16 Jul
It's actually something surprising, I didn't particularly know it, but until now I haven't had any surgery.
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13 sats \ 4 replies \ @OneOneSeven 16 Jul
This is why I chose no anesthesia when I had three wisdom teeth pulled at some rinkydink dentist office this year hahahah.
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34 sats \ 2 replies \ @SpaceHodler 16 Jul
But the anesthesia used in dentistry is local, not general? General anesthesia is a completely different ball game.
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23 sats \ 1 reply \ @OneOneSeven 16 Jul
For wisdom teeth they often offer general anesthesia, at least where I am in the US they do. I passed on it and they gave local instead with novocaine in the gums.
I felt most of it which sucked a lot, but still preferable to getting knocked out.
If I'm dying, obviously go ahead and knock me out, do what you gotta do: #454660
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34 sats \ 0 replies \ @itsrealfake 16 Jul
I took the local anesthetic for wisdom teeth... it was a real strange thing to have my jaw jerked about and to hear the crunching of the teeth as they broke.
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34 sats \ 0 replies \ @south_korea_ln OP 16 Jul
Sounds like the reasonable thing to do. I sedated myself with alcohol last time i had a tooth problem~~
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13 sats \ 3 replies \ @0xbitcoiner 16 Jul
"We're getting closer to working out how general anaesthetics work and why they work, but there's really a lot more that's not known at this point in time."

WTF! 😕

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23 sats \ 1 reply \ @fm 16 Jul
Science cant really explain stuff as simple as water... let alone complex chemical reactions in an organ we dont fully understand..
on the other hand, we produce vaccines in months.. But dont worry and repeat after me: Safe and Effective :)
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0 sats \ 0 replies \ @Bell_curve 16 Jul
Moderna mRNA
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13 sats \ 0 replies \ @south_korea_ln OP 16 Jul
Exactly my thoughts first time i found out. Even if it's a 2020 article, still lots of questions are still unanswered.
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